The Effect of Luteal Phase Support on Pregnancy Rates of the Stimulated Intrauterine Insemination Cycles in Couples with Unexplained Infertility
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Abstract:
Background To assess the efficacy of luteal phase support (LPS) with vaginal progesterone (P) on pregnancy rates of the stimulated intrauterine insemination (IUI) cycles in couples with unexplained infertility (UEI). MaterialsAndMethods This was a single-center, prospective, randomized, blinded control trial undertaken at a tertiary care university fertility center between October 2007 and December 2008. A total of 200 couples with UEI underwent 511 consecutive stimulated IUI cycles. Clomiphene citrate (Cc) and human menopausal gonadotropin (hMG) were used for ovulation induction. After IUI, patients were randomized into two groups. The study group (n=98) received intra-vaginal P (Cyclogest) for LPS. The patients randomized into the control group (n=102) received no drug for LPS. The main outcome was the comparison of clinical pregnancy rate (PR) and live birth rate (BR) per cycle and patient between the control and study groups. Results There were no differences in demographic characteristics between the groups. PR per patient and cycle were similar in the study group (30.6% and 11.5%, respectively) and in the control group [25.5% and 10.03%, respectively] (p>0.05). There were no statistically significant increases in BR per patient and cycle between the study group (19.4% and 7.5%, respectively) and the control group [14.7% and 5.7%, respectively] (p> 0.05). Conclusion Administration of vaginal P (Cyclogest) for LPS does not improve the reproductive outcome of stimulated IUI cycles (Registeration Number: IRCT1389 01283737N1).
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the effect of luteal phase support on pregnancy rates of the stimulated intrauterine insemination cycles in couples with unexplained infertility
background: to assess the efficacy of luteal phase support (lps) with vaginal progesterone (p) on pregnancy rates of the stimulated intrauterine insemination (iui) cycles in couples with unexplained infertility (uei). materials and methods: this was a single-center, prospective, randomized, blinded control trial undertaken at a tertiary care university fertility center between october 2007 and ...
full textEffect of Pertubation on Pregnancy Rates before Intrauterine Insemination Treatment in Patients with Unexplained Infertility
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Luteal phase support in intrauterine insemination cycles
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full textEffect of Pertubation on Pregnancy Rates before Intrauterine Insemination Treatment in Patients with Unexplained Infertility
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Journal title
volume 4 issue 2
pages 51- 56
publication date 2010-06-01
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